There has been a conceptual shift in how Alzheimer’s disease is defined. Alzheimer’s disease is now considered to form a continuum, encompassing pathologic changes without clinical symptoms (preclinical AD), mild cognitive impairment (MCI) due to AD and AD dementia.1–3
References: 1. Dubois B et al. Alzheimers Dement. 2016;12(3):292–323. 2. Alzheimer’s Association. Diagnostic criteria and guidelines. Available at: www.alz.org/research/for_researchers/diagnostic-criteria-guidelines (Accessed January 2021). 3. Sperling RA et al. Alzheimers Dement. 2011;7(3):280–92. 4. Baxi SM et al. Assessing the preparedness of the Australian health care system infrastructure for an Alzheimer’s disease-modifying therapy. Available at: www.rand.org/pubs/research_reports/RR2891.html (Accessed January 2021). 5. National Institute on Aging. (2017). Symptoms and diagnosis of Alzheimer’s disease: What is mild cognitive impairment? Available at: www.nia.nih.gov/health/what-mildcognitiveimpairment(Accessed January 2021).